CPR deals primarily with NCEs and therefore the majority of projects are bound by confidentiality. However we do have a number of non-proprietary methods available as listed below.

CPR has developed and validated more than 100 analytical methods for compounds from small molecules to higher molecular weight peptides used in first time in human studies. Due to confidentiality restrictions these methods are not listed below.

For more information on CPR’s library of methods please contact Andrew Dinan.

Fully Validated Assays

Drug

Matrix

Acetyl-L-carnitine / L-carnitine

urine

Carboplatin

plasma

Carnitine

muscle / plasma

Clioquinol

plasma

Dextromethorphan / Total Dextrorphan

plasma

Dextrorphan (Total)

plasma

Diclofenac /  4'Hydroxydiclofenac

skin / plasma

Diclofenac

plasma

Dihydroartemisinin

plasma

Etoposide

plasma

Everolimus

whole blood

Fentanyl

plasma

Ibuprofen

plasma

Itraconazole / hydroxy-itraconazole

plasma

Lidocaine /  MEGX

skin / plasma

L-tyrosine

plasma

Nestorone

plasma

Nicotine

plasma

Octyl salicylate

plasma

Oxycodone / Noroxycodone

plasma

Phenylepherine (Total)

plasma

Piperaquine

plasma

Propionyl L-carnitine / L-carnitine

plasma

Pseudoephedrine

plasma

r-Flurbiprofen

plasma

r/s-Ibuprofen

plasma

Vancomycin

plasma

Biomarker Assays (Qualified)

Drug

Metabolites / Analytes

Matrix

Glucagon

-

plasma

Vessel Dilator

-

plasma

3-OMG

-

plasma

Androgens

Total testosterone

serum

 

A4 - Androstenedione

 

 

DHEA - Dehydroepiandrosterone

 

Estrogens

E2 - Estradiol

plasma

 

E3 - Estriol

 

 

Progesterone

 

Estrogens

E2 - Estradiol

urine

 

E3 - Estriol

 

 

Progesterone

 

Estrogens

E2 - Estradiol

saliva

 

E3 - Estriol

 

 

Progesterone

 

Tocopherol Alpha DL

-

plasma

Tocopherol phosphate

-

plasma

VEGF

-

plasma

Motilin

-

serum

Biomarkers Assays in Development

Drug

Metabolites / Analytes

Matrix

Catecholamines

Epinephrine

plasma

 

Norepinephrine

 

 

Dopamine

 

Amyloid beta peptides (Primate)

1-38, 38 AA

csf

 

1-40, 40 AA

 

 

1-42, 42 AA

 

Amyloid beta peptides (Human)

1-38, 38 AA

csf

 

1-40, 40 AA

 

 

1-42, 42 AA

 

Estrogens

E1 - Estrone

serum

 

E2 - Estradiol

 

 

E3 - Estriol

 

 

E4 - Estetrol

 

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